Enzymes in cancer.III. Triosephosphate isomerase activity of human blood serum in normal individuals and in individuals with various pathological conditions

All in all, clinical science characterizes anaemia disease as less tally of a red platelet. This illness is exceptionally successive in India and a few pieces of the entire world. This isn't straightforwardly influencing illness however the maker and initiator of numerous other blood-related issues. Biomedical has effectively built up a testing technique for the recognizable proof of such infection and sorted out the strategy for computing the quantity of check or scope of red platelets in human bodies. In view of a correlation of such information with ordinary human blood attributes specialists can distinguish the level of the pallor and its connected stage. This requires time like conventional blood revealing just as the precision of testing philosophy. With the help of this article, another method of recognizing similar information inside a brief timeframe is introduced. By processing the ordinary human platelet check with anaemia influenced blood through the bioelectronics circuit, it will be useful to sort out the presence of the illness. Rather than utilizing genuine blood, a substance blend comparable to human blood serum has been thought of and for sickness, synthetic creation has been modified. This may change results for genuine human blood however then circuit changes may assist us with improving the outcomes. The sugar meter and heart meter are as of now utilized in everyday life by normal individuals without the assistance of specialists. These commonsense outcomes may lead such instrument makers for building up the gadget for sickliness identification.

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Action of UV radiation on human blood serum under normal and pathological conditions

Bulletin of Experimental Biology and Medicine ◽

10.1007/bf00807487 ◽

1977 ◽

Vol 83 (4) ◽

pp. 497-499 ◽

Cited By ~ 1

Author(s):

V. Yu. Kulikov ◽

V. P. Kaznacheev ◽

L. I. Kolesnikova

Keyword(s):

Blood Serum ◽

Uv Radiation ◽

Human Blood ◽

Human Blood Serum ◽

Pathological Conditions

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Human blood serum proteome changes after 6 hours of sleep deprivation at night

Sleep Science and Practice ◽

10.1186/s41606-021-00066-2 ◽

2021 ◽

Vol 5 (1) ◽

Author(s):

Alvhild Alette Bjørkum ◽

Ana Carrasco Duran ◽

Berven Frode ◽

Dola Sinha Roy ◽

Karen Rosendahl ◽

...

Keyword(s):

Sleep Deprivation ◽

Blood Serum ◽

Human Blood ◽

Biological Process ◽

Human Blood Serum ◽

Molecular Function ◽

Biological Databases ◽

Related Disorder ◽

Cancer Data ◽

Pathological Conditions

Abstract Background The aim of this study was to discover significantly changed proteins in human blood serum after loss of 6 h sleep at night. Furthermore, to reveal affected biological process- and molecular function categories that might be clinically relevant, by exploring systems biological databases. Methods Eight females were recruited by volunteer request. Peripheral venous whole blood was sampled at 04:00 am, after 6 h of sleep and after 6 h of sleep deprivation. We used within-subjects design (all subjects were their own control). Blood serum from each subject was depleted before protein digestion by trypsin and iTRAQ labeling. Labled peptides were analyzed by mass spectrometry (LTQ OritrapVelos Elite) connected to a LC system (Dionex Ultimate NCR-3000RS). Results We identified 725 proteins in human blood serum. 34 proteins were significantly differentially expressed after 6 h of sleep deprivation at night. Out of 34 proteins, 14 proteins were up-regulated, and 20 proteins were down-regulated. We emphasized the functionality of the 16 proteins commonly differentiated in all 8 subjects and the relation to pathological conditions. In addition, we discussed Histone H4 (H4) and protein S100-A6/Calcyclin (S10A6) that were upregulated more than 1.5-fold. Finally, we discussed affected biological process- and molecular function categories. Conclusions Overall, our study suggest that acute sleep deprivation, at least in females, affects several known biological processes- and molecular function categories and associates to proteins that also are changed under pathological conditions like impaired coagulation, oxidative stress, immune suppression, neurodegenerative related disorder, and cancer. Data are available via ProteomeXchange with identifier PXD021004.

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